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Various locomotor tests have been used to study the action of neuroleptics on locomotor behavior. However, data obtained from the study of animals using the various methods have been largely confounded by discrepancies in conditions of testing, such as the use of opaque vs transparent test cages, darkness vs illumination during testing, and the room housing of the animals. We have developed a test procedure in which four groups of rats were placed in either a cage or a test cage with one of the four different conditions of testing. A control group of rats was placed in a familiar home cage, a no drug group was placed in a familiar home cage, and three groups were tested on one of the following conditions: With the illumination off; With illumination on and with one of the following: – exposure to an unfamiliar conspecific, – placing in a novel environment, or – placement in a novel environment with an unfamiliar conspecific. We then analyzed data from the four groups of animals to evaluate the effect of these different conditions. It was found that some factors, such as room housing or dark vs light conditions, had a significant impact on the locomotor response, and that the light intensity was a critical factor. Additionally, although some differences were seen between these conditions, all testing conditions produced similar response patterns. Our results indicate that the effects of drugs on locomotor activity are similar under the various conditions of testing. The data from our study thus provide a framework for analyzing locomotor data from other studies.Q:

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